Description

2',4'-Difluoro-Biphenyl-3-Methanamine is a high-purity, fluorinated biphenyl derivative with a primary amine functional group, serving as a critical advanced pharmaceutical intermediate. Its molecular structure makes it a valuable building block for synthesizing complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. This compound is essential for research and development chemists and process scale-up teams in the global pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorinated motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, especially in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro-biphenyl scaffold can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new chemical entities and reaction pathways involving fluorinated aromatics.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific, high-value fluorinated aromatic amines.

Basic Information

Product Name	2',4'-Difluoro-Biphenyl-3-Methanamine
CAS No.	177976-51-1
Molecular Formula	C13H11F2N
Molecular Weight	219.23 g/mol
Synonyms	3-(Aminomethyl)-2',4'-difluorobiphenyl; [1,1'-Biphenyl]-3-methanamine, 2',4'-difluoro-; 2',4'-Difluoro-3-biphenylmethanamine; 2',4'-Difluoro-[1,1'-biphenyl]-3-ylmethanamine; (2',4'-Difluoro[1,1'-biphenyl]-3-yl)methanamine; 3-Aminomethyl-2',4'-difluorobiphenyl
EINECS	Contact for details

Quality Control

Our 2',4'-Difluoro-Biphenyl-3-Methanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to light or air should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.