Description

Fmoc-D-3-Benzothienylalanine is a protected, non-natural amino acid derivative of significant importance in modern peptide synthesis. This chiral building block, with CAS number 177966-61-9, is specifically engineered for the solid-phase and solution-phase construction of complex peptides and peptidomimetics. It is an essential reagent for pharmaceutical R&D, enabling the exploration of novel therapeutic candidates with enhanced stability and bioactivity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated synthesis of peptides containing the non-natural benzothienylalanine side chain.
• Pharmaceutical Research: Used in the development of peptide-based drugs, enzyme inhibitors, and receptor agonists/antagonists targeting various diseases.
• Peptidomimetic Design: Incorporation into peptide backbones to enhance metabolic stability, membrane permeability, and binding affinity.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for high-throughput screening in drug discovery.
• Bioconjugation: Serves as a handle for site-specific labeling or functionalization of peptides and proteins.
• Academic & Industrial R&D: Fundamental research tool in biochemistry and medicinal chemistry for studying protein-protein interactions and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-D-3-Benzothienylalanine
CAS No.	177966-61-9
Molecular Formula	C26H21NO4S
Molecular Weight	443.52 g/mol
Synonyms	Fmoc-D-3-(2-Benzothienyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1-benzothiophen-3-yl)-D-alanine; Fmoc-D-Bta-OH; Fmoc-D-3-Benzothienyl-Ala-OH; N-Fmoc-3-(benzo[b]thiophen-3-yl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(benzo[b]thiophen-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-3-Benzothienylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.