Description

Boc-n-Me-D-Nva-Oh CAS NO 177659-77-7 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and side-chain protection in complex molecular assemblies. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, peptidomimetics, and as a key building block in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce modified norvaline residues into lead compounds.
• Bioconjugation: Serves as a protected linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Proteomics & Biochemistry: Employed in the synthesis of custom peptides for enzyme substrate studies, protein-protein interaction analysis, and epitope mapping.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.
• Academic Research: Used in university and institutional labs for teaching advanced synthetic techniques and exploring new peptide-based materials.

Basic Information

Product Name	Boc-n-Me-D-Nva-Oh
CAS No.	177659-77-7
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-D-norvaline; Boc-N-Me-D-Nva-OH; tert-Butyloxycarbonyl-N-methyl-D-norvaline; (S)-2-((tert-Butoxycarbonyl)(methyl)amino)pentanoic acid; D-Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-; Boc-N-methyl-D-2-aminopentanoic acid; N-Methyl-N-Boc-D-norvaline
EINECS	Contact for details

Quality Control

Our Boc-n-Me-D-Nva-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.