Description

3-Fluoro-4-(Trifluoromethoxy)Phenol is a high-value fluorinated phenolic intermediate with a unique trifluoromethoxy substituent. This compound is critical for introducing enhanced lipophilicity, metabolic stability, and electron-withdrawing properties into advanced molecular architectures. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated monomers used in high-performance liquid crystal displays (LCDs).
• Polymer Modification: Incorporated as a functional monomer to create specialty polymers with improved chemical resistance and surface properties.
• Organic Electronics: Acts as a starting material for synthesizing electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Chemical Research: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethoxy)Phenol
CAS No.	177596-38-2
Molecular Formula	C7H4F4O2
Molecular Weight	196.10 g/mol
Synonyms	4-Hydroxy-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-4-hydroxy-1-(trifluoromethoxy)benzene; 3-Fluoro-4-hydroxy-α,α,α-trifluoroanisole; 3-Fluoro-4-(trifluoromethoxy)benzenol; Phenol, 3-fluoro-4-(trifluoromethoxy)-; F3CO-Ph-F-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-(Trifluoromethoxy)Phenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your project.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.