Description

Carafiban is a high-purity, non-peptide platelet aggregation inhibitor belonging to the glycoprotein IIb/IIIa receptor antagonist class. This compound is of significant interest in pharmaceutical research and development for its potent antiplatelet activity. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers developing next-generation antithrombotic agents. The global demand for such specialized intermediates is driven by the ongoing need for improved cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of advanced antithrombotic drug candidates.
• Biochemical Research: Used as a reference standard or tool compound in studies of platelet physiology and thrombosis mechanisms.
• API Development: Serves as the core active moiety in the development and scale-up of finished dosage forms targeting arterial thrombosis.
• Preclinical Studies: Employed in animal models to evaluate efficacy and safety profiles of novel antiplatelet therapies.
• Process Chemistry: Utilized in route scouting and optimization for the commercial manufacturing of glycoprotein IIb/IIIa antagonists.

Basic Information

Product Name	Carafiban
CAS No.	177563-40-5
Molecular Formula	C20H28N4O4S
Molecular Weight	420.53 g/mol
Synonyms	Carafiban; L-734,217; (2S)-2-[(4-{4-[(Aminosulfonyl)amino]phenyl}-1-piperidinyl)carbonyl]amino]-3-(1-naphthalenyl)propanoic acid; N-[(1S)-1-[[(4-{4-[(Aminosulfonyl)amino]phenyl}-1-piperidinyl)carbonyl]amino]-2-(1-naphthyl)ethyl]glycine; L 734217; L734217.
EINECS	Contact for details

Quality Control

Our Carafiban is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While produced to meet exacting internal standards, we can discuss alignment with specific pharmacopeial guidelines (e.g., ICH Q3A/B, USP) based on project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.