Description

H-p-Fluoro-D-Phe-Ome Hcl is a fluorinated, non-natural amino acid derivative with the CAS number 176896-72-3, specifically designed for advanced pharmaceutical research and development. This compound is a critical chiral building block, valued for its role in modulating the biological activity, metabolic stability, and binding affinity of peptide-based therapeutics. It is essential for medicinal chemists and process development scientists working in peptide synthesis, drug discovery, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Peptide Research: Used to incorporate fluorinated phenylalanine analogs into peptide sequences to study structure-activity relationships (SAR).
• Drug Discovery: Serves as a building block for creating libraries of compounds in high-throughput screening for new therapeutic targets.
• Metabolic Stability Studies: The fluorine atom is used to block metabolic sites, making it valuable for developing peptides with improved in vivo stability.
• API Process Development: Employed in the scale-up and optimization of manufacturing processes for fluorinated peptide APIs.
• Biochemical Tool: Utilized in academic and industrial research to probe enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	H-p-Fluoro-D-Phe-Ome Hcl
CAS No.	176896-72-3
Molecular Formula	C10H12FNO2 • HCl
Molecular Weight	233.66 g/mol (Free base: 197.21 g/mol)
Synonyms	(R)-Methyl 2-amino-3-(4-fluorophenyl)propanoate hydrochloride; D-4-Fluorophenylalanine methyl ester hydrochloride; Methyl (R)-2-amino-3-(4-fluorophenyl)propanoate hydrochloride; (R)-4-Fluoro-D-phenylalanine methyl ester HCl; p-Fluoro-D-Phe-OMe • HCl; F-D-Phe-OMe • HCl; D-p-Fluorophenylalanine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-p-Fluoro-D-Phe-Ome Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.