Description

H-Thr-Nhme Hcl CAS NO 176543-45-6 is a high-purity, protected amino acid derivative, specifically the hydrochloride salt of N-Methyl-L-threonine amide. This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the L-threonine residue with a protected side chain and modified C-terminus.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein folding, and as a standard in analytical method development.
• Proteomics & Diagnostics: Utilized in the design and production of specialized peptide sequences for diagnostic assays and biomarker discovery.
• Academic & R&D Laboratories: Serves as a fundamental reagent for synthetic organic chemistry and medicinal chemistry projects in academic and industrial settings.

Basic Information

Product Name	H-Thr-Nhme Hcl
CAS No.	176543-45-6
Molecular Formula	C6H13N2O2•HCl
Molecular Weight	196.64 g/mol
Synonyms	L-Threonine, N-methyl-, amide, hydrochloride; N-Methyl-L-threoninamide hydrochloride; H-Thr-NHMe•HCl; (2S,3R)-2-Amino-3-hydroxy-N-methylbutanamide hydrochloride; Thr(NHMe)•HCl; Fmoc-Thr(tBu)-NHMe precursor; Protected L-threonine amide hydrochloride; Peptide synthesis building block 176543-45-6
EINECS	Contact for details

Quality Control

Our H-Thr-Nhme Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.