Description

(2S,4R)-Fmoc-4-Amino-1-Boc-Pyrrolidine-2-Carboxylic Acid is a high-purity, dual-protected amino acid derivative essential for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and orthogonal deprotection strategies in complex molecule assembly. It is primarily utilized by the pharmaceutical and biotechnology industries for the development of novel therapeutic peptides, peptidomimetics, and as a key building block in medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial Fmoc/Boc-protected building block for the controlled introduction of the constrained (2S,4R)-4-aminoproline scaffold into peptide chains.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based therapeutics, protease inhibitors, and conformationally restricted bioactive molecules.
• Peptidomimetic Design: Serves as a core scaffold for creating stable, drug-like analogs that mimic natural peptides, improving metabolic stability and bioavailability.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening against biological targets.
• Bioconjugation: Acts as a specialized linker or functional handle for attaching peptides to other molecules, surfaces, or biomolecules.
• Academic & Contract Research: A vital reagent for universities and CROs conducting fundamental research in organic synthesis, peptide science, and chemical biology.

Basic Information

Product Name	(2S,4R)-Fmoc-4-Amino-1-Boc-Pyrrolidine-2-Carboxylic Acid
CAS No.	176486-63-8
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	Fmoc-4-NH2-Pro(Boc)-OH; (2S,4R)-1-(tert-Butoxycarbonyl)-4-amino-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pyrrolidine-2-carboxylic acid; (2S,4R)-4-Amino-1-Boc-pyrrolidine-2-carboxylic acid Fmoc derivative; 1-Boc-4-NH2-Pro(Fmoc)-OH; (2S,4R)-1-Boc-4-Amino-Fmoc-proline; 4-Amino-1-Boc-pyrrolidine-2-carboxylic acid, 9-fluorenylmethyl ester; Fmoc-Amp(Boc)-OH; trans-4-Amino-L-proline derivative (Fmoc/Boc protected)
EINECS	Contact for details

Quality Control

Our (2S,4R)-Fmoc-4-Amino-1-Boc-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, chiral purity, and chemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.