Description

n-Fmoc-L-Threonol CAS NO 176380-53-3 is a protected amino alcohol derivative, specifically the Fmoc-protected form of L-threoninol. This compound is a crucial chiral building block in solid-phase peptide synthesis (SPPS), where it serves as a key intermediate for introducing the threonine side chain with orthogonal protection. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of threonine analogs into peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, hormones, and antimicrobial peptides.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or labels.
• Combinatorial Chemistry: A valuable scaffold for generating libraries of compounds in drug discovery programs.
• Protecting Group Chemistry: The Fmoc group allows for selective deprotection under mild basic conditions, enabling complex multi-step syntheses.
• Academic & Industrial Research: Critical for biochemical studies involving protein-protein interactions and structure-activity relationships (SAR).

Basic Information

Product Name	n-Fmoc-L-Threonol
CAS No.	176380-53-3
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-L-threoninol; (2S,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1,3-butanediol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threoninol; N-Fmoc-L-threoninol; L-Threoninol, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (2S,3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1,3-butanediol; 1,3-Butanediol, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S,3R)-
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Threonol is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.