Description

Roxifiban CAS NO 176022-59-6 is a potent and selective non-peptide antagonist of the platelet glycoprotein IIb/IIIa receptor (integrin αIIbβ3). This compound is a critical research tool and pharmaceutical intermediate for the development of novel antiplatelet and antithrombotic therapies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and fine chemical manufacturers focused on cardiovascular drug discovery and development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of next-generation antiplatelet drugs.
• Biochemical Research: Used as a selective probe to study the structure, function, and signaling pathways of the integrin αIIbβ3 receptor in platelet aggregation and thrombosis.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and safety profiles of glycoprotein IIb/IIIa antagonists.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex therapeutic agents targeting cardiovascular diseases.

Basic Information

Product Name	Roxifiban
CAS No.	176022-59-6
Molecular Formula	C29H41N5O6S
Molecular Weight	587.73 g/mol
Synonyms	Roxifiban; DMP 802; SC-54701; (2S)-2-[[(3S)-3-[[(4-Carbamimidoylphenyl)formamido]methyl]-4-oxo-2-oxetanyl]carbonylamino]-3-(4-hydroxyphenyl)propanoic acid; 1-(4-Carbamimidoylbenzoyl)-L-tyrosyl-4-amidinobenzylamide cyclic Lactone; GP IIb/IIIa Antagonist DMP 802
EINECS	Contact for details

Quality Control

Our Roxifiban is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere. Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.