Description

α-Conotoxin Mii is a selective and potent peptide neurotoxin originally derived from the venom of marine cone snails. This compound is a valuable research tool for studying and characterizing specific subtypes of nicotinic acetylcholine receptors (nAChRs) in neuroscience and pharmacology. It is primarily utilized by academic researchers, pharmaceutical R&D teams, and biotechnology companies engaged in neurological research, ion channel studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective antagonist for α3β2 and α6/α3β2β3 nAChR subtypes, it is essential for mapping receptor distribution and function in the central and peripheral nervous systems.
• Pharmacological Studies: Used in vitro and in vivo to investigate the role of specific nAChR subtypes in pain pathways, addiction, neuroprotection, and cognitive function.
• Drug Discovery & Development: Serves as a critical reference standard and tool compound for screening and validating new drug candidates targeting nicotinic receptors.
• Ion Channel Characterization: Employed in electrophysiology (e.g., patch-clamp) and binding assays to study the biophysical and pharmacological properties of neuronal nAChRs.
• Biochemical Reagent: Used in the development of diagnostic assays and as a ligand for receptor isolation and purification processes.
• Toxicology & Venom Research: A key compound for comparative studies on conotoxin structure-activity relationships and venom evolution.

Basic Information

Product Name	α-Conotoxin Mii
CAS No.	175735-93-0
Molecular Formula	C92H138N30O27S5
Molecular Weight	2236.6 g/mol
Synonyms	α-Conotoxin MII; α-Conotoxin MII; Conotoxin MII; MII Conotoxin; α-CTx MII; α-CTx MII; Nicotinic Acetylcholine Receptor Antagonist (α3β2 subtype); 13-Mer peptide (Disulfide bonds: Cys1-Cys3, Cys2-Cys4, Cys5-Cys6)
EINECS	Contact for details

Quality Control

Our α-Conotoxin Mii is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solvent Residues	Meets ICH guidelines
Biological Activity	Verified by nAChR binding or functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.