Description

Fmoc-Gly-Oh,[2-13C] is a stable isotope-labeled derivative of the amino acid glycine, specifically labeled with carbon-13 at the 2-position, and protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is essential for advanced research and development in fields requiring precise molecular tracking and analysis. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for applications in peptide synthesis, metabolic studies, and as a critical building block in drug discovery.

Application

• Peptide Synthesis: Serves as a carbon-13 labeled building block in solid-phase and solution-phase peptide synthesis for the incorporation of isotopically labeled glycine residues.
• Metabolic Pathway Tracing: Used in NMR spectroscopy and mass spectrometry-based studies to elucidate biochemical pathways and metabolic fluxes.
• Proteomics Research: Enables the synthesis of isotopically labeled peptides and proteins for quantitative proteomics, protein turnover studies, and structural analysis.
• Pharmaceutical R&D: Acts as a key intermediate in the development of radiolabeled or stable isotope-labeled drug candidates for pharmacokinetic and pharmacodynamic studies.
• Biomolecular NMR: Provides a source of site-specific isotopic labeling to simplify complex NMR spectra and facilitate the determination of protein structure and dynamics.
• Standards for Analytical Chemistry: Employed as an internal standard in LC-MS and GC-MS analyses to ensure accurate quantification of glycine and related compounds.

Basic Information

Product Name	Fmoc-Gly-Oh,[2-13C]
CAS No.	175453-19-7
Molecular Formula	C₁₇H₁₅¹³CNO₄
Molecular Weight	313.31 g/mol (for ¹³C labeled form)
Synonyms	Fmoc-glycine-2-13C; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine-2-13C; (2-13C)-N-Fmoc-glycine; Fmoc-Gly-13C-OH; 9-Fluorenylmethyloxycarbonyl-glycine-2-13C; N-Fmoc-glycine-2-13C; Fmoc-13C-glycine; Glycine-2-13C, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Oh,[2-13C] is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high isotopic and chemical purity, meeting the exacting standards required for research and development. Certificates of Analysis (COA) are provided, detailing specifications for isotopic enrichment, chemical purity, and identity confirmation via techniques such as NMR and HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % ¹³C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.