Description

n-Fmoc-D-Glutamic Acid 1-Methyl Ester is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the side chain carboxyl group of D-glutamic acid, enabling precise and sequential peptide chain assembly. It is a critical building block for research and development laboratories, pharmaceutical companies, and CROs/CMOs focused on creating novel peptides, peptidomimetics, and bioconjugates with complex structures.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of D-glutamic acid into peptide sequences.
• Pharmaceutical Research: Used in the development of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug delivery systems.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation: The protected side chain allows for selective deprotection and subsequent conjugation with other molecules, such as dyes, polymers, or cytotoxic agents.
• Chemical Biology Probes: Utilized in the synthesis of labeled peptides for studying protein-protein interactions, enzyme activity, and cellular processes.
• Process Development: Employed in scaling up GMP-grade peptide APIs (Active Pharmaceutical Ingredients) for clinical and commercial manufacturing.

Basic Information

Product Name	n-Fmoc-D-Glutamic Acid 1-Methyl Ester
CAS No.	175452-89-8
Molecular Formula	C21H21NO6
Molecular Weight	383.40 g/mol
Synonyms	Fmoc-D-Glu(OMe)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 1-methyl ester; D-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-methyl ester; Fmoc-D-Glutamic Acid α-Methyl Ester; N-α-Fmoc-D-glutamic acid 1-methyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-glutamic acid 1-methyl ester
EINECS	Contact for details

Quality Control

Our n-Fmoc-D-Glutamic Acid 1-Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.