Description

2-Bromo-4-Trifluoromethoxyaniline is a halogenated aniline derivative featuring both bromine and a trifluoromethoxy substituent, making it a versatile and valuable aromatic amine intermediate. This compound is particularly significant for its role in the synthesis of complex molecules, where its unique substitution pattern enables the introduction of specific functional groups and modulates electronic properties. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Dye and Pigment Chemistry: Acts as an intermediate in the development of specialized dyes and pigments, contributing to color fastness and unique spectral properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions like Buchwald-Hartwig amination or Suzuki coupling for creating complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-4-Trifluoromethoxyaniline
CAS No.	175278-17-8
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	1-Amino-2-bromo-4-(trifluoromethoxy)benzene; 2-Bromo-4-(trifluoromethoxy)aniline; 2-Bromo-4-(trifluoromethoxy)benzenamine; 4-Trifluoromethoxy-2-bromoaniline; Benzenamine, 2-bromo-4-(trifluoromethoxy)-; 2-Bromo-α,α,α-trifluoro-p-anisidine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Trifluoromethoxyaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or stored in dark conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.