Description

Benzyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value, multi-functional pyrimidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic combination of reactive sites—the benzyl ester, chloro, and trifluoromethyl groups—enabling precise molecular construction for complex target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is utilized to build active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of chemical probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Facilitates methodological studies in cross-coupling reactions, ester transformations, and heterocyclic chemistry for novel compound libraries.

Basic Information

Product Name	Benzyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	175137-29-8
Molecular Formula	C13H8ClF3N2O2
Molecular Weight	316.66 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, phenylmethyl ester; Benzyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate; 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid benzyl ester; 175137-29-8; Bn-2-Cl-4-CF3-Pyrimidine-5-COO; Benzyl 2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylate
EINECS	Contact for details

Quality Control

Our production of Benzyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.