Description

Methyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is a high-value pyrimidine derivative and a key synthetic intermediate in advanced organic chemistry. Its core value lies in its trifluoromethyl and chloro substituents, which are crucial for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances efficacy and environmental stability.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronics and specialty polymers.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling reagent in the design of chemical probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, fluorinated pyrimidine cores.

Basic Information

Product Name	Methyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate
CAS No.	175137-27-6
Molecular Formula	C7H4ClF3N2O2
Molecular Weight	240.57 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid methyl ester; Methyl 2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylate; 5-Pyrimidinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, methyl ester; 2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester; Methyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.