Description

[His19]-Charybdotoxin CAS NO 175069-96-2 is a site-directed mutant of the potent potassium channel blocker charybdotoxin, where the native lysine residue at position 19 is substituted with histidine. This specific modification is critical for advanced electrophysiological and biochemical research, enabling precise studies of ion channel structure, function, and ligand-receptor interactions. It is an essential tool for researchers and developers in neuroscience, pharmacology, and toxicology, particularly for those investigating potassium channel dynamics and developing novel therapeutic agents.

Application

• Ion Channel Research: A key pharmacological tool for blocking high-conductance calcium-activated potassium (BK) channels in electrophysiology studies.
• Structure-Activity Relationship (SAR) Studies: Used to investigate the role of specific amino acid residues in toxin binding affinity and selectivity.
• Neurological Disorder Modeling: Employed in research models to understand the pathophysiology of diseases linked to potassium channel dysfunction.
• Drug Discovery Screening: Serves as a reference compound and probe in high-throughput screening assays for identifying new channel modulators.
• Biochemical Assay Development: Used in the development and validation of binding assays (e.g., radio-ligand or fluorescence-based) for potassium channels.
• Academic & Pharmaceutical R&D: Fundamental research in universities and biopharma companies focused on neuropharmacology and peptide engineering.

Basic Information

Product Name	[His19]-Charybdotoxin
CAS No.	175069-96-2
Molecular Formula	C185H284N54O53S7
Molecular Weight	~4290.9 g/mol
Synonyms	Charybdotoxin K19H; Charybdotoxin (Lys19→His); CTX K19H; His(19)-CTX; Potassium channel blocker toxin K19H mutant; ShK-like toxin analogue; Scorpion toxin analogue; IBT-02
EINECS	Contact for details

Quality Control

Our [His19]-Charybdotoxin is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional activity. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Biological Activity	Confirmed by functional assay (e.g., channel blockade)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.