Description

[Gln12]-Charybdotoxin is a site-directed, synthetic analog of the potent neurotoxin charybdotoxin, specifically engineered with a glutamine substitution at position 12. This modification is critical for advanced biochemical and pharmacological research, particularly in the study of high-conductance calcium-activated potassium (BK) channels. It serves as an essential tool compound for neuroscientists, pharmacologists, and ion channel researchers in academic, pharmaceutical, and biotechnology sectors.

Application

• Ion Channel Research: Selective probing and inhibition studies of BK (Maxi-K) potassium channels to understand gating mechanisms and structure-function relationships.
• Neuropharmacology: Used as a reference standard and molecular tool in the development and screening of novel therapeutics targeting potassium channel dysfunction.
• Biophysical Studies: Employed in electrophysiology (e.g., patch-clamp experiments) and binding assays to determine channel affinity and kinetics.
• Structural Biology: Aids in X-ray crystallography and NMR studies to elucidate toxin-channel interaction sites and conformational changes.
• Signal Transduction Research: Investigating the role of BK channels in cellular processes such as neuronal excitability, muscle contraction, and hormone secretion.

Basic Information

Product Name	[Gln12]-Charybdotoxin
CAS No.	175069-95-1
Molecular Formula	C185H284N54O55S7
Molecular Weight	~4290.9 g/mol
Synonyms	Charybdotoxin (Gln12); [Gln12]-ChTX; CTX-Gln12; L-Charybdotoxin (12-Gln); Potassium channel toxin α-KTx 1.1 (Gln12) analog; Iberiotoxin-related peptide; ShK-like toxin analog; Synthetic charybdotoxin mutant
EINECS	Contact for details

Quality Control

Our [Gln12]-Charybdotoxin is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, sequence verification, and bioactivity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single-Chain Proportion (HPLC)	≥ 90%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Biological Activity	Confirmed by functional assay (e.g., channel inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.