Description

5,7-Bis(Trifluoromethyl)-3-Cyano-2-(Methylthio)Pyrazolo[1,5-A]Pyrimidine is a high-value, multi-functional heterocyclic building block characterized by its unique trifluoromethyl and cyano substituents. This compound is critical for advanced research and development, offering significant potential to modulate the physicochemical properties of target molecules, including lipophilicity, metabolic stability, and binding affinity. It is primarily sought by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, as well as by material scientists exploring advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research, where the trifluoromethyl groups enhance bioavailability and metabolic resistance.
• Agrochemical Active Ingredient Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its structural complexity for targeted biological activity.
• Material Science Research: Serves as a precursor for organic semiconductors, light-emitting diodes (OLEDs), and non-linear optical (NLO) materials due to its electron-deficient pyrimidine core.
• Chemical Biology & Probe Development: Employed in the design of molecular probes and tags for studying biological processes and enzyme inhibition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	5,7-Bis(Trifluoromethyl)-3-Cyano-2-(Methylthio)Pyrazolo[1,5-A]Pyrimidine
CAS No.	174842-48-9
Molecular Formula	C11H4F6N4S
Molecular Weight	338.23 g/mol
Synonyms	2-(Methylthio)-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile; 5,7-Bis(trifluoromethyl)-2-(methylthio)pyrazolo[1,5-a]pyrimidine-3-carbonitrile; Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5,7-bis(trifluoromethyl)-2-(methylthio)-; 174842-48-9; 5,7-Bis(trifluoromethyl)-2-methylsulfanyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 5,7-Bis(Trifluoromethyl)-3-Cyano-2-(Methylthio)Pyrazolo[1,5-A]Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay (HPLC), related substances, and spectroscopic identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure storage areas are segregated from such materials to prevent contamination or decomposition. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.