Description

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-Nitro-Tyr-Asp-Oh CAS NO 174838-79-0 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critical for researchers and developers requiring precise, quantitative measurement of protease activity in complex biological matrices. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit development for studying enzyme kinetics and inhibitor screening.

Application

• Protease Activity Assays: As a specialized fluorogenic substrate for the detection and quantification of specific proteolytic enzymes, including trypsin and related serine proteases.
• Drug Discovery & High-Throughput Screening (HTS): Enables the identification and characterization of novel protease inhibitors in pharmaceutical research pipelines.
• Biochemical Research: Used in mechanistic studies to understand enzyme-substrate interactions, cleavage specificity, and catalytic efficiency.
• Diagnostic Development: Serves as a key component in the development of clinical and research-grade diagnostic kits for detecting abnormal protease levels.
• Quality Control in Biologics: Employed to monitor and validate the activity and purity of enzyme preparations used in therapeutic manufacturing.

Basic Information

Product Name	Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-Nitro-Tyr-Asp-Oh
CAS No.	174838-79-0
Molecular Formula	C₆₇H₁₀₈N₂₄O₁₈
Molecular Weight	1545.7 g/mol
Synonyms	Abz-RVKRGLA-mNO₂-Y-D-OH; o-Aminobenzoic acid-Arg-Val-Lys-Arg-Gly-Leu-Ala-3-Nitro-Tyr-Asp-OH; Fluorogenic Peptide Substrate for Trypsin; (Abz)-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(3-NO₂)-Asp-OH; Peptide Substrate 174838-79-0; m-Nitro-Tyrosine containing fluorogenic substrate; Abz-RVKRGLA-Y(3-NO₂)-D-OH
EINECS	Contact for details

Quality Control

Our Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-Nitro-Tyr-Asp-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analysis, including HPLC purity determination, mass spectrometry (MS) for identity confirmation, and functional activity validation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	Conforms to internal reference assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.