Description

Fmoc-Hyp(Bzl)-Oh CAS NO 174800-02-3 is a protected amino acid derivative, specifically an Fmoc-protected hydroxyproline with a benzyl (Bzl) group on the hydroxyl function. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of modified proline residues into complex peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of peptides on resin.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating labeled or functionalized peptides for diagnostic and research applications.
• Collagen-Mimetic Peptides: Essential for synthesizing peptides that mimic the structure of collagen, where hydroxyproline is a crucial component.
• Peptidomimetics & Drug Discovery: Employed in the design of stable, bioactive peptide analogs with improved pharmacological properties.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on organic chemistry, medicinal chemistry, and protein engineering.

Basic Information

Product Name	Fmoc-Hyp(Bzl)-Oh
CAS No.	174800-02-3
Molecular Formula	C27H25NO5
Molecular Weight	443.49 g/mol
Synonyms	Fmoc-Hyp(Bzl)-OH; Fmoc-trans-4-Hydroxy-L-proline(Bzl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(benzyloxy)-L-proline; Fmoc-4-(Benzyloxy)-L-proline; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(benzyloxy)pyrrolidine-2-carboxylic acid; Fmoc-L-Hyp(Bzl)-OH; Fmoc-4-Hyp(Bzl)-OH; Fmoc-Hyp(OBzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Hyp(Bzl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	-40° to -50° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.