Description

α-Trifluoromethyl-β-Butyrolactone CAS NO 174744-18-4 is a specialized fluorinated lactone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl group, enabling the efficient introduction of fluorine atoms to enhance the properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated heterocycles and active pharmaceutical ingredients (APIs), where fluorine substitution can improve metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or building block for synthesizing fluorinated polymers and specialty materials with unique surface properties, chemical resistance, and thermal stability.
• Ligand and Catalyst Development: Employed in the synthesis of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	α-Trifluoromethyl-β-Butyrolactone
CAS No.	174744-18-4
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	4,4,4-Trifluoro-3-hydroxybutanoic acid lactone; 3-Hydroxy-4,4,4-trifluorobutanoic acid γ-lactone; 3-Hydroxy-4,4,4-trifluorobutyric acid lactone; α-(Trifluoromethyl)-β-butyrolactone; 4-(Trifluoromethyl)dihydrofuran-2(3H)-one; TFMBL; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our α-Trifluoromethyl-β-Butyrolactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC for residual solvents, to ensure it meets exacting specifications for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its sensitivity to moisture and strong alkali, ensure the container is kept tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.