Description

2-Chloro-4-(Piperazin-1-Yl)Pyrimidine is a versatile and high-value pharmaceutical intermediate, primarily utilized as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). Its molecular structure, featuring both a reactive chloro-pyrimidine moiety and a piperazine ring, makes it an essential precursor for medicinal chemistry and drug discovery programs. This compound is particularly critical for research and manufacturing within the pharmaceutical and biotechnology sectors, where it is used to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug molecules, particularly kinase inhibitors and other targeted therapies.
• API (Active Pharmaceutical Ingredient) Synthesis: Used in the multi-step production of final active pharmaceutical ingredients for various therapeutic areas.
• Medicinal Chemistry & Drug Discovery: A valuable scaffold for research chemists in designing and optimizing new chemical entities (NCEs) during lead optimization phases.
• Bioconjugation & Chemical Biology: The reactive chloro group allows for further functionalization, making it useful in creating probes and conjugates for biological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and pharmacology.

Basic Information

Product Name	2-Chloro-4-(Piperazin-1-Yl)Pyrimidine
CAS No.	174728-03-1
Molecular Formula	C8H12ClN5
Molecular Weight	213.67 g/mol
Synonyms	4-(Piperazin-1-yl)-2-chloropyrimidine; 2-Chloro-4-piperazin-1-ylpyrimidine; 2-Chloro-4-(1-piperazinyl)pyrimidine; 2-Chloro-4-piperazinylpyrimidine; 174728-03-1; Pyrimidine, 2-chloro-4-(1-piperazinyl)-; 2-Chloro-4-(piperazin-1-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Piperazin-1-Yl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.