Description

Talnetant CAS NO 174636-26-1 is a high-purity, non-peptide tachykinin NK3 receptor antagonist. This compound is a critical research chemical and pharmaceutical intermediate, valued for its specific biological activity in modulating neurokinin signaling pathways. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions for preclinical studies and drug discovery programs targeting central nervous system disorders.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics.
• Neuroscience Studies: Used as a selective tool compound in vitro and in vivo to investigate the physiological and pathophysiological roles of the NK3 receptor.
• Drug Discovery Programs: Employed in high-throughput screening (HTS) and lead optimization for conditions such as schizophrenia, depression, and anxiety.
• Biochemical Assay Development: Acts as a critical reagent for validating assay systems and studying receptor-ligand interactions.
• Academic Research: Supports fundamental research in neuropharmacology and signal transduction mechanisms at universities and research institutes.
• GMP Manufacturing: Suitable for use in the synthesis of clinical trial materials under controlled Good Manufacturing Practice (GMP) conditions, where applicable.

Basic Information

Product Name	Talnetant
CAS No.	174636-26-1
Molecular Formula	C₂₃H₂₅N₃O₃
Molecular Weight	391.47 g/mol
Synonyms	Talnetant; SB-223412; (S)-N-(1-(3-(1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide; SB 223412; SB223412; UNII-6F1A8WY8VW; 6F1A8WY8VW; (3S)-1-[3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-N-methyl-N-(4-phenylpiperidin-4-yl)acetamide
EINECS	Contact for details

Quality Control

Every batch of Talnetant is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay purity and impurity profiles. Our quality commitment supports applications from early-stage research through to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.