Description

5-Trifluoromethyl-2-Pyridinesulfonyl Chloride is a high-value organosulfur building block characterized by its reactive sulfonyl chloride group and electron-deficient pyridine core. This compound is essential for the synthesis of sulfonamide derivatives, which are key pharmacophores in modern medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical reagent for constructing sulfonamide-based drug candidates in areas such as oncology, antiviral, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Chemical Biology & Proteomics: Serves as a versatile coupling agent for labeling proteins or modifying biomolecules due to its reactivity with amines.
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials with specific electronic properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-Trifluoromethyl-2-Pyridinesulfonyl Chloride
CAS No.	174485-72-4
Molecular Formula	C6H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)pyridine-2-sulfonyl chloride; 5-Trifluoromethylpyridine-2-sulfonyl chloride; 2-Sulfonylchloride-5-trifluoromethylpyridine; 5-Trifluoromethyl-2-pyridylsulfonyl chloride; 174485-72-4; 5-CF3-2-Pyridinesulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-2-Pyridinesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.