Description

(2,5-Dioxopyrrolidin-1-Yl) 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(1H-Indol-3-Yl)Propanoate is a specialized, high-purity chemical building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise and efficient amide bond formation, particularly in complex molecule assembly. It is primarily utilized in the pharmaceutical and biotechnology sectors for the synthesis of peptides and other bioactive molecules, where reliable quality and consistent performance are paramount.

Application

• Peptide Synthesis: As an activated ester derivative of Fmoc-Tryptophan, it serves as a key reagent for the solid-phase and solution-phase synthesis of peptides, enabling the efficient incorporation of the tryptophan residue.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic agents, including potential drug candidates targeting neurological and oncological pathways.
• Bioconjugation: Facilitates the labeling and modification of proteins, antibodies, and other biomolecules for diagnostic and research applications.
• Protecting Group Chemistry: The Fmoc (9-fluorenylmethoxycarbonyl) group provides a base-labile protecting strategy for amines, essential in multi-step synthetic sequences.
• Academic & Industrial R&D: A vital tool for chemists in universities, contract research organizations (CROs), and chemical development labs exploring new synthetic methodologies.
• Combinatorial Chemistry: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	(2,5-Dioxopyrrolidin-1-Yl) 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(1H-Indol-3-Yl)Propanoate
CAS No.	174080-12-7
Molecular Formula	C30H25N3O6
Molecular Weight	523.54 g/mol
Synonyms	Fmoc-Trp-OSu; Fmoc-Tryptophan N-hydroxysuccinimide ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tryptophan N-succinimidyl ester; Nα-Fmoc-Nin-H-L-tryptophan succinimidyl ester; Fmoc-L-Trp-OSu; Fmoc-Tryptophan-OSu; N-Fmoc-L-tryptophan succinimidyl ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-2-[(9H-fluoren-9-ylmethoxy)formamido]-3-(1H-indol-3-yl)propanoate
EINECS	Contact for details

Quality Control

Our (2,5-Dioxopyrrolidin-1-Yl) 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(1H-Indol-3-Yl)Propanoate is manufactured under strict quality management systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize condensation and exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.