Description

S-Methyl-L-Thiocitrulline Acetate Salt is a chemically modified derivative of the amino acid L-citrulline, specifically designed for advanced biochemical and pharmacological research. This compound is of significant interest for its role as a potent and selective inhibitor of nitric oxide synthase (NOS) isoforms, enabling critical studies in cardiovascular and neurological research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for inflammation, ischemia, and neurodegenerative diseases.

Application

• Nitric Oxide Synthase (NOS) Inhibition Studies: Serves as a crucial research tool for selectively inhibiting neuronal NOS (nNOS) to investigate its role in neurotransmission, neurotoxicity, and pain pathways.
• Cardiovascular Research: Used in preclinical models to study the effects of NOS inhibition on blood pressure regulation, vascular tone, and ischemia-reperfusion injury.
• Inflammation and Immunology Research: Applied in cellular assays to elucidate the complex role of nitric oxide in inflammatory responses and immune system modulation.
• Neurodegenerative Disease Models: Employed in research targeting conditions like Alzheimer's disease, Parkinson's disease, and stroke, where dysregulated NO production is implicated.
• Biochemical Reagent: Acts as a high-purity reference standard and intermediate in the synthesis of more complex pharmacological agents and diagnostic probes.
• Enzyme Mechanism Studies: Provides insights into the binding mechanisms and catalytic activity of nitric oxide synthase enzymes due to its structural analogy to the natural substrate.

Basic Information

Product Name	S-Methyl-L-Thiocitrulline Acetate Salt
CAS No.	174063-92-4
Molecular Formula	C8H17N3O3S • C2H4O2
Molecular Weight	279.33 g/mol (Free base: 219.30 g/mol)
Synonyms	S-Methyl-L-thiocitrulline acetate; L-Thiocitrulline, S-methyl-, acetate; (2S)-2-Amino-5-[(methylsulfanyl)carbamimidamido]pentanoic acid acetate; S-Methylthiocitrulline acetate salt; NOS Inhibitor; nNOS inhibitor; SMTC acetate salt
EINECS	Contact for details

Quality Control

Our S-Methyl-L-Thiocitrulline Acetate Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.