Description

Afobazole (Hydrochloride) CAS NO 173352-39-1 is a selective anxiolytic compound belonging to the class of 2-mercaptobenzimidazole derivatives. It is valued for its pharmacological profile, offering anxiolytic effects without significant sedation, muscle relaxation, or amnesia, which are common side effects of classical benzodiazepines. This makes it a critical intermediate and active ingredient for research and development within the pharmaceutical industry, particularly for novel neuropsychiatric therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in anxiolytic and neuroprotective drug formulations.
• Neurological Research: A key compound in preclinical and clinical research for studying anxiety disorders, stress-related conditions, and cognitive functions.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Drug Discovery & Development: Used as a lead compound or intermediate in the synthesis and development of next-generation anxiolytic agents.
• Academic & Institutional Research: Utilized in universities and research institutes for pharmacological studies and mechanistic investigations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished dosage forms.

Basic Information

Product Name	Afobazole (Hydrochloride)
CAS No.	173352-39-1
Molecular Formula	C16H21N3O2•HCl
Molecular Weight	323.82 g/mol
Synonyms	Afobazole HCl; Fabomotizole Hydrochloride; 2-[2-(Morpholin-4-yl)ethylthio]-5-ethoxybenzimidazole Dihydrochloride; 5-Ethoxy-2-[(2-morpholinoethyl)thio]benzimidazole Hydrochloride; NSC 339024; OCM-1; MG-1
EINECS	Contact for details

Quality Control

Our Afobazole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade pharmaceutical standards. Certificates of Analysis (COA) with detailed HPLC purity, related substances, and residual solvent data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.