Description

H-Leu-Arg-Arg-Arg-Arg-Phe-D-Ala-Phe-Cys(Npys)-Nh2 is a synthetic, chemically modified peptide featuring a C-terminal amide and a nitro-2-pyridinesulfenyl (Npys) protecting group on the cysteine residue. This compound is of significant value in biochemical and pharmaceutical research, particularly for studying protease activity and signal transduction pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of enzyme inhibitors, cell-penetrating peptides, and novel therapeutic agents.

Application

• Biochemical research as a substrate or inhibitor for specific proteases, including furin and related proprotein convertases.
• Development of cell-penetrating peptides (CPPs) due to its polyarginine sequence, facilitating intracellular delivery of cargo molecules.
• Use in pharmaceutical R&D for studying peptide-based drug delivery systems and targeted therapeutics.
• Tool compound in academic research for investigating protein-protein interactions and enzyme kinetics.
• Potential precursor for the synthesis of more complex, disulfide-linked peptide conjugates, leveraging the reactive Npys-protected cysteine.
• Component in diagnostic assay development for detecting specific enzymatic activities.

Basic Information

Product Name	H-Leu-Arg-Arg-Arg-Arg-Phe-D-Ala-Phe-Cys(Npys)-Nh2
CAS No.	173324-17-9
Molecular Formula	C68H112N30O13S2
Molecular Weight	1589.9 g/mol
Synonyms	Leu-Arg-Arg-Arg-Arg-Phe-D-Ala-Phe-Cys(Npys)-NH2; LR4RFDAPC(Npys)-NH2; Polyarginine Peptide Derivative; Npys-protected Cysteine Peptide; Furin Substrate Analog; CPP Sequence; H-Leu-Arg-Arg-Arg-Arg-Phe-D-Ala-Phe-Cys(3-nitro-2-pyridinesulfenyl)-Amide; Acetylated Polyarginine Peptide Fragment
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC and mass spectrometry to verify identity, purity, and composition. Certificates of Analysis (COA) detailing purity, assay, and related substances are available upon request. We adhere to GMP principles for manufacturing consistency suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.