Description

((Cys31,Nva34)-Neuropeptide Y (27-36))2 is a synthetic, disulfide-bridged cyclic peptide analog derived from the C-terminal region of Neuropeptide Y (NPY). This compound is a valuable research-grade biochemical tool designed for studying NPY receptor interactions and signaling pathways, particularly those involving the Y2 receptor subtype. It is essential for researchers and developers in the fields of neuroscience, endocrinology, and pharmaceutical discovery who require high-purity, well-characterized peptide ligands for receptor binding assays, functional studies, and structure-activity relationship (SAR) analysis.

Application

• Neuroscience Research: As a selective ligand for investigating the physiological and pathological roles of Neuropeptide Y Y2 receptors in the central and peripheral nervous systems.
• Pharmacological Assay Development: Used as a reference standard or tracer in competitive receptor binding assays (e.g., radioligand binding) to screen and characterize novel NPY receptor agonists or antagonists.
• Endocrine System Studies: Research tool for exploring NPY's effects on food intake, energy homeostasis, anxiety, stress response, and cardiovascular function.
• Structure-Activity Relationship (SAR) Analysis: Key compound for understanding the impact of specific amino acid substitutions (Cys31, Nva34) on peptide conformation, receptor affinity, and biological activity.
• Biochemical Reagent: Serves as a critical reagent in cell-based assays and signal transduction studies to elucidate downstream effects of Y2 receptor activation.
• Academic and Pharmaceutical R&D: Fundamental material for basic research and early-stage drug discovery programs targeting NPY receptors for metabolic, neurological, or cardiovascular disorders.

Basic Information

Item	Details
Product Name	((Cys31,Nva34)-Neuropeptide Y (27-36))2
CAS No.	172997-92-1
Molecular Formula	C92H144N26O24S2
Molecular Weight	Contact for details
Synonyms	Cyclo([Cys31, Nva34]NPY(27-36)); NPY Y2 Receptor Agonist (Cys31, Nva34) analog; Disulfide-cyclized NPY (27-36) analog; [Cys31, Nva34]-NPY (27-36) dimer; Neuropeptide Y fragment (27-36) cyclic analog; NPY (27-36) (Cys31,Nva34) cyclic peptide; c[Cys31,Nva34]NPY(27-36)
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under strict quality control protocols. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results for purity (HPLC), molecular weight confirmation (MS), and peptide content. We adhere to industry best practices for synthetic peptide production to support reproducible scientific research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Retention time and mass spectrum correspond to reference
Purity (HPLC)	≥ 95% (Area % at 214 nm)
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.