Description

Sibrafiban CAS NO 172927-65-0 is a potent and selective non-peptide glycoprotein IIb/IIIa (GP IIb/IIIa) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its antiplatelet activity, which is crucial for preventing thrombotic events. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel cardiovascular therapeutics and anticoagulant agents.

Application

• Pharmaceutical R&D: Primary application in the research and development of antiplatelet and antithrombotic drugs.
• Biochemical Research: Used as a reference standard or active pharmaceutical ingredient (API) in studies targeting the GP IIb/IIIa receptor pathway.
• Preclinical Studies: Employed in animal models to evaluate efficacy and safety profiles for cardiovascular applications.
• Mechanism of Action Studies: A key tool compound for investigating platelet aggregation and thrombosis mechanisms.
• Analytical Standard: Serves as a high-purity standard for quality control and analytical method development (e.g., HPLC, LC-MS).

Basic Information

Product Name	Sibrafiban
CAS No.	172927-65-0
Molecular Formula	C20H28N4O4
Molecular Weight	388.46 g/mol
Synonyms	Sibrafiban; Ro 48-3657; 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid, 2-[[(Ethoxycarbonyl)amino]methyl]-, ethyl ester; Ethyl 2-[[(ethoxycarbonyl)amino]methyl]-4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetate; Ro 48-3657/000; Ro-48-3657
EINECS	Contact for details

Quality Control

Our Sibrafiban is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques such as HPLC and NMR, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.