Description

Fmoc-(S)-3-Amino-2-Hydroxypropionic Acid is a high-purity, non-natural amino acid derivative featuring orthogonal protecting groups for advanced peptide synthesis. This compound is essential for the controlled introduction of serine-like, hydroxylated amino acid residues into complex peptide chains, enabling the synthesis of peptides with enhanced stability or specific biological activity. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, used to incorporate β-hydroxy-α-amino acid structures.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of peptide drugs targeting metabolic diseases, oncology, and infectious diseases.
• Bioconjugation & Linker Chemistry: Utilized to create peptide-drug conjugates (PDCs) or to attach functional molecules via its carboxylic acid and hydroxyl groups.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, protein-protein interactions, and the development of enzyme inhibitors.
• Glycopeptide Mimetics: Acts as a scaffold for developing mimetics of O-linked glycopeptides, important in immunology and vaccine design.
• Material Science: Used to synthesize functionalized polymers and hydrogels with bioactive peptide sequences for biomedical applications.

Basic Information

Product Name	Fmoc-(S)-3-Amino-2-Hydroxypropionic Acid
CAS No.	172721-23-2
Molecular Formula	C₁₈H₁₇NO₅
Molecular Weight	327.33 g/mol
Synonyms	Fmoc-Ser-OH(β); (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic Acid; Fmoc-L-β-Homoserine; Fmoc-β-HomoSer-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-homoserine; Fmoc-3-amino-2-hydroxypropanoic acid; Nα-Fmoc-L-β-homoserine; Fmoc-β-hSer-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-2-Hydroxypropionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.