Description

Fmoc-L-β-Homovaline CAS NO 172695-33-9 is a protected, non-proteinogenic amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it enables the precise incorporation of a sterically hindered, β-branched side chain into peptide sequences, allowing researchers to explore structure-activity relationships and enhance peptide stability. It is primarily needed by pharmaceutical R&D teams, biotech companies, and academic laboratories engaged in developing novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to modulate bioavailability, receptor binding, and metabolic stability.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with enhanced pharmacological properties.
• Chemical Biology: Used in the synthesis of labeled peptides or activity-based probes for studying enzyme function and protein-protein interactions.
• Antibiotic Development: Potential building block for novel antimicrobial peptides (AMPs) with modified side chains.
• Material Science: Research into peptide-based polymers and biomaterials where side-chain engineering is required.

Basic Information

Product Name	Fmoc-L-β-Homovaline
CAS No.	172695-33-9
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-β-homo-L-Val-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-homo-L-valine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3-dimethylpentanoic acid; Fmoc-L-β-Homovaline; Fmoc-β-homovaline; N-Fmoc-β-homo-L-valine; Fmoc-β-Hval-OH; Fmoc-3-amino-3-methyl-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homovaline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.