Description

Ac-Nle-Gln-His-D-Phe-Arg-D-Trp-Gly-Nh2 is a synthetic peptide analog of α-Melanocyte-Stimulating Hormone (α-MSH), designed for enhanced stability and biological activity. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in modulating melanogenesis and potential anti-inflammatory effects. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on dermatology, metabolic disorders, and pigmentary research.

Application

• Biochemical Research: Used as a high-purity reference standard and tool compound for studying melanocortin receptor (MCR) signaling pathways, particularly MC1R.
• Pharmaceutical R&D: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics for skin pigmentation disorders, inflammation, and appetite regulation.
• Cosmeceutical Studies: Investigated for potential applications in topical formulations aimed at skin tanning, photoprotection, or anti-aging.
• Academic Research: Employed in university and institutional labs for fundamental studies in endocrinology, peptide chemistry, and drug discovery.
• Peptide Library Synthesis: Acts as a specialized building block for constructing focused libraries to explore structure-activity relationships (SAR) within the melanocortin peptide family.

Basic Information

Product Name	Ac-Nle-Gln-His-D-Phe-Arg-D-Trp-Gly-Nh2
CAS No.	172617-89-9
Molecular Formula	C52H72N18O11
Molecular Weight	1109.24 g/mol
Synonyms	Ac-[Nle4, D-Phe7]-α-MSH (4-10); Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 analog; α-MSH analog; Melanotan I fragment; MT-I; Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 related peptide; [N-Acetyl-Nle4, D-Phe7]-α-MSH(4-10); Afamelanotide precursor
EINECS	Contact for details

Quality Control

Our Ac-Nle-Gln-His-D-Phe-Arg-D-Trp-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.