Description

3-Quinolinecarboxylic Acid, 5-Amino-7-(3-Amino-1-Pyrrolidinyl)-1-Cyclopropyl-8-Ethoxy-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering critical structural complexity for targeted therapeutic action. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for the development of new antibacterial agents with improved efficacy and spectrum of activity.
• API Synthesis: Serves as a key precursor in the multi-step manufacturing process of complex antibiotic Active Pharmaceutical Ingredients (APIs).
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control and method development.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale production studies for new drug molecules.
• Academic & Institutional Research: Used in university and research institute settings for studies in organic synthesis and antimicrobial pharmacology.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 5-Amino-7-(3-Amino-1-Pyrrolidinyl)-1-Cyclopropyl-8-Ethoxy-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	172602-90-3
Molecular Formula	C19H24FN5O4
Molecular Weight	405.42 g/mol
Synonyms	5-Amino-7-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-8-ethoxy-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; PD 161148; ABT-492 intermediate; Cethromycin intermediate; Advanced fluoroquinolone intermediate; 1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-4-oxo-7-(3-aminopyrrolidin-1-yl)-5-aminoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 5-Amino-7-(3-Amino-1-Pyrrolidinyl)-1-Cyclopropyl-8-Ethoxy-6-Fluoro-1,4-Dihydro-4-Oxo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.