Description

His-Cys-Lys-Phe-Trp-Trp CAS NO 172546-75-7 is a synthetic hexapeptide composed of the amino acids Histidine, Cysteine, Lysine, Phenylalanine, and two Tryptophan residues. This sequence is of significant interest in biochemical research and pharmaceutical development due to its potential bioactive properties and utility as a reference standard. It is primarily utilized by research institutions and biotechnology companies engaged in peptide synthesis, structure-activity relationship (SAR) studies, and the development of novel therapeutic agents. The compound's specific sequence offers a valuable tool for investigating molecular interactions and biological pathways.

Application

• Biochemical Research: Serves as a critical reference standard and building block in peptide chemistry and proteomics studies.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based therapeutics, including enzyme inhibitors or receptor ligands.
• Structure-Activity Relationship (SAR) Studies: Essential for analyzing how specific amino acid sequences influence biological activity and stability.
• Academic Research: Employed in university laboratories for teaching advanced peptide synthesis techniques and molecular biology.
• Bioconjugation & Probe Development: The cysteine residue provides a thiol group for site-specific labeling and conjugation with other molecules.
• Quality Control Standard: Used to calibrate analytical instruments like HPLC and Mass Spectrometry in quality assurance laboratories.

Basic Information

Product Name	His-Cys-Lys-Phe-Trp-Trp
CAS No.	172546-75-7
Molecular Formula	C48H58N14O8S
Molecular Weight	991.14 g/mol
Synonyms	HCK(F)WW; H-C-K-F-W-W-OH; Hexapeptide HCK(F)WW; L-Histidyl-L-cysteinyl-L-lysyl-L-phenylalanyl-L-tryptophyl-L-tryptophan; Histidine-Cysteine-Lysine-Phenylalanine-Tryptophan-Tryptophan; HCK(F)WW peptide; H-Cys-Lys-Phe-Trp-Trp; 172546-75-7
EINECS	Contact for details

Quality Control

Our His-Cys-Lys-Phe-Trp-Trp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity. Allow the sealed vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.