Description

H-Lys(Boc)-Pna is a protected amino acid derivative, specifically Nα-Boc-Nε-Cbz-L-lysine p-nitroanilide, widely used as a key synthetic intermediate in peptide chemistry. This compound is essential for researchers and manufacturers requiring high-purity building blocks for the controlled synthesis of complex peptides and peptidomimetics. It is primarily utilized in pharmaceutical R&D, academic research, and the production of active pharmaceutical ingredients (APIs) where precise molecular assembly is critical.

Application

• Peptide Synthesis Intermediate: Serves as a crucial protected building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Used in the development and scale-up of novel therapeutic peptides and protein-based drugs.
• Bioconjugation: Acts as a reagent for attaching peptide sequences to other molecules, polymers, or surfaces in bioconjugation chemistry.
• Enzyme Substrate Analog: Can be employed in biochemical assays as a substrate analog for studying protease and peptidase enzyme activity.
• Chemical Biology Probes: Utilized in the synthesis of labeled peptides for use as probes in cellular and molecular biology studies.
• Custom Peptide Service: A fundamental raw material for contract research and manufacturing organizations (CROs/CMOs) offering custom peptide services.

Basic Information

Product Name	H-Lys(Boc)-Pna
CAS No.	172422-76-3
Molecular Formula	C25H32N4O7
Molecular Weight	500.55 g/mol
Synonyms	Nα-Boc-Nε-Cbz-L-lysine p-nitroanilide; Boc-Lys(Cbz)-pNA; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[(phenylmethoxy)carbonyl]-L-lysine 4-nitroanilide; Fmoc-Lys(Cbz)-pNA; Boc-Lys(Z)-pNA; N-(tert-Butoxycarbonyl)-N'-(benzyloxycarbonyl)-L-lysine 4-nitroanilide; L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-, 4-nitroanilide
EINECS	Contact for details

Quality Control

Our H-Lys(Boc)-Pna is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.