Description

n-[N′-Fmoc-(2′-Aminoethyl)]Glycine is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its role as a critical building block in the production of complex peptides and peptidomimetics, offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled assembly of custom peptide sequences.
• Peptidomimetic Drug Development: Used to incorporate non-natural amino acid backbones, enhancing metabolic stability and bioavailability of therapeutic candidates.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold for generating diverse compound libraries for high-throughput screening.
• Bioconjugation and Linker Chemistry: Utilized in the synthesis of peptide-drug conjugates (PDCs) and other bioconjugates due to its reactive amine and carboxyl groups.
• Research & Development: Fundamental reagent in academic and industrial R&D for studying protein-protein interactions and designing novel bioactive molecules.
• API Intermediate Production: Acts as a sophisticated intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-[N′-Fmoc-(2′-Aminoethyl)]Glycine
CAS No.	172405-45-7
Molecular Formula	C₁₉H₂₀N₂O₄
Molecular Weight	340.38 g/mol
Synonyms	Fmoc-N-amidoethyl-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(2-aminoethylamino)acetic acid; Fmoc-Aee-Gly-OH; 2-[[2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]ethyl]amino]acetic acid; N-Fmoc-2,2'-iminodi(ethylamine)acetic acid; N-(2-Aminoethyl)-N-(carboxymethyl)-9-fluorenylmethoxycarbonylamine; Fmoc-8-amino-3,6-dioxaoctanoic acid (related linker); AEEA linker derivative
EINECS	Contact for details

Quality Control

Our n-[N′-Fmoc-(2′-Aminoethyl)]Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.