Description

Proteolipid Protein 178-191 CAS NO 172228-98-7 is a defined peptide fragment derived from the proteolipid protein (PLP), a major component of central nervous system myelin. This synthetic peptide is a critical research tool for investigating the molecular basis of autoimmune demyelinating diseases, such as multiple sclerosis. It is primarily utilized by pharmaceutical R&D teams, academic immunology and neurology laboratories, and diagnostic developers focused on neuroinflammation and autoimmune disorder research.

Application

• Immunological Research: Used as a specific antigen to study T-cell epitopes and immune responses in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis.
• Antibody Production & Characterization: Serves as an immunogen for generating and screening monoclonal or polyclonal antibodies targeting the PLP protein.
• Diagnostic Development: Potential use as a coating antigen or standard in ELISA or other immunoassays designed to detect autoantibodies in patient sera.
• Drug Discovery & Vaccine Research: Employed in high-throughput screening assays to identify potential therapeutic compounds or tolerizing vaccines that modulate the immune response to PLP.
• Biomarker Studies: Used in epitope mapping and biomarker discovery projects to understand disease progression and patient stratification in demyelinating conditions.
• Neuroscience & Cell Biology: Applied in studies investigating myelin structure, oligodendrocyte biology, and the mechanisms of myelin repair and degradation.

Basic Information

Product Name	Proteolipid Protein 178-191
CAS No.	172228-98-7
Molecular Formula	C70H115N19O22S
Molecular Weight	1546.8 g/mol
Synonyms	PLP (178-191); Myelin Proteolipid Protein Fragment 178-191; PLP Peptide 178-191; H-Gly-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Asp-Ser-Lys-Tyr-OH; PLP178-191; Autoantigen PLP Peptide; Myelin PLP Determinant; Multiple Sclerosis-Associated Peptide Antigen
EINECS	Contact for details

Quality Control

Every batch of Proteolipid Protein 178-191 is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for research applications. Our standard grade is characterized by HPLC purity ≥95% and is supplied with comprehensive analytical data. A detailed Certificate of Analysis (COA), including results for purity (HPLC), molecular weight confirmation (MS), and peptide content, is provided with each shipment. Custom synthesis to higher purity grades (e.g., >98%) or with specific modifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Retention time and mass consistent with reference
Purity (HPLC)	≥ 95%
Molecular Weight	1546.8 ± 2 Da
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.