Description

3-Bromo-5-(Trifluoromethyl)Benzyl Alcohol CAS NO 172023-97-1 is a versatile fluorinated aromatic building block characterized by its reactive benzyl alcohol and bromo substituents. This compound is essential for introducing the trifluoromethylphenyl moiety into complex molecular architectures, a key strategy for modulating lipophilicity and metabolic stability in advanced materials and pharmaceuticals. It is primarily sought by research chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for use in cross-coupling reactions and as a precursor to various functionalized intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to create complex biaryl systems.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones to alter thermal stability, chemical resistance, and optical properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research programs exploring structure-activity relationships (SAR).

Basic Information

Product Name	3-Bromo-5-(Trifluoromethyl)Benzyl Alcohol
CAS No.	172023-97-1
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	[3-Bromo-5-(trifluoromethyl)phenyl]methanol; (3-Bromo-5-trifluoromethylphenyl)methanol; 1-Bromo-3-(hydroxymethyl)-5-(trifluoromethyl)benzene; α-(3-Bromo-5-trifluoromethylphenyl)methanol; 3-Bromo-α-(trifluoromethyl)benzenemethanol; Benzenemethanol, 3-bromo-α-(trifluoromethyl)-; 3-Bromo-5-trifluoromethylbenzyl alcohol
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-5-(Trifluoromethyl)Benzyl Alcohol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specification parameters are provided with every shipment. We support cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.