Description

Fmoc-D-Pro-Cl CAS NO 171905-37-6 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and controlled introduction of the D-proline residue into peptide chains, enabling the production of complex, non-natural peptides with enhanced stability and biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise construction of custom peptides, especially those incorporating D-amino acids for metabolic stability.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting various diseases.
• Bioconjugation & Probe Development: Used to create labeled peptides for research applications in imaging, diagnostics, and target identification.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic & Institutional Research: Fundamental building block for studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Contract Manufacturing (CDMO): A reliable raw material for contract development and manufacturing organizations specializing in peptide APIs under cGMP guidelines.

Basic Information

Product Name	Fmoc-D-Pro-Cl
CAS No.	171905-37-6
Molecular Formula	C21H20ClNO4
Molecular Weight	385.84 g/mol
Synonyms	Fmoc-D-prolyl chloride; (R)-N-(9-Fluorenylmethoxycarbonyl)prolyl chloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-proline chloride; Fmoc-D-Proline acid chloride; Fmoc-D-Pro-Cl; N-Fmoc-D-proline chloride; D-Proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, chloride; Fmoc-D-Proline chloride
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pro-Cl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, typically exceeding 98% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity (IR, NMR), assay, chiral purity, and impurity profile. We support compliance with relevant pharmaceutical guidelines, and specifications can be aligned with customer requirements for advanced R&D or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DCM, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.