Description

n-[2-Amino-4-Chloro-6-[[(1R,4S)-4-(Hydroxymethyl)-2-Cyclopenten-1-Yl]Amino]-5-Pyrimidinyl]Formamide is a sophisticated chiral nucleoside analog intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of novel antiviral and anticancer therapeutics, where precise stereochemistry is critical for biological activity. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside analog antiviral agents.
• Anticancer Drug Research: Serves as a building block for developing targeted chemotherapeutic compounds.
• Biochemical Research: Used in studies investigating enzyme mechanisms and nucleotide metabolism.
• Process Chemistry: Employed in route scouting and scale-up optimization for Active Pharmaceutical Ingredient (API) manufacturing.
• Chiral Synthesis: Utilized as a starting material for creating enantiomerically pure compounds due to its defined (1R,4S) stereochemistry.
• Labeled Compound Synthesis: A potential substrate for the preparation of isotopically labeled compounds for metabolic and pharmacokinetic studies.

Basic Information

Product Name	n-[2-Amino-4-Chloro-6-[[(1R,4S)-4-(Hydroxymethyl)-2-Cyclopenten-1-Yl]Amino]-5-Pyrimidinyl]Formamide
CAS No.	171887-04-0
Molecular Formula	C11H14ClN5O2
Molecular Weight	283.71 g/mol
Synonyms	4-Amino-2-chloro-6-(((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)pyrimidine-5-carboxamide; (1R,4S)-N-(2-Amino-4-chloro-5-carbamoylpyrimidin-6-yl)-4-(hydroxymethyl)cyclopent-2-en-1-amine; Carbocyclic Nucleoside Analog Intermediate; Cyclopentenyl Pyrimidine Formamide Derivative; Chiral Cyclopentene Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our n-[2-Amino-4-Chloro-6-[[(1R,4S)-4-(Hydroxymethyl)-2-Cyclopenten-1-Yl]Amino]-5-Pyrimidinyl]Formamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.