Description

Fmoc-α-Me-D-Orn(Boc)-Oh is a protected, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound matters as a critical building block for constructing complex peptides with enhanced metabolic stability and specific stereochemical configurations. Pharmaceutical researchers and peptide manufacturers need it for the development of novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of custom peptides with α-methylated ornithine residues.
• Peptidomimetic Drug Discovery: Used to introduce conformational constraints and improve the proteolytic stability of peptide-based drug candidates.
• Antimicrobial Peptide (AMP) Research: Facilitates the creation of novel AMP analogs with modified cationic side chains for enhanced activity.
• Bioconjugation and Probe Development: Serves as a functionalized intermediate for labeling peptides or attaching payloads in bioconjugate chemistry.
• Academic and Industrial R&D: Essential for studying structure-activity relationships (SAR) in peptide science and medicinal chemistry programs.

Basic Information

Product Name	Fmoc-α-Me-D-Orn(Boc)-Oh
CAS No.	171860-40-5
Molecular Formula	C₂₆H₃₂N₂O₆
Molecular Weight	468.55 g/mol
Synonyms	Fmoc-α-Me-D-Orn(Boc)-OH; N-α-Fmoc-N-δ-Boc-α-methyl-D-ornithine; Fmoc-D-α-methylornithine(Boc)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid; N-δ-(tert-Butoxycarbonyl)-N-α-(9-fluorenylmethoxycarbonyl)-α-methyl-D-ornithine; Boc-D-Orn(α-Me)-OH Fmoc derivative; Fmoc-D-aMeOrn(Boc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Orn(Boc)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.