Description

2-Fmoc-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for constructing complex peptide chains, particularly in the development of pharmaceutical candidates and bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides on resin.
• Pharmaceutical Research: Building block for the synthesis of peptide-based drug candidates, including enzyme inhibitors and receptor ligands.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify novel bioactive compounds.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for therapeutic or diagnostic applications.
• Academic Research: Employed in studies exploring peptide structure-activity relationships and novel synthetic methodologies.
• Process Development: Serves as a starting material or intermediate in the scale-up and optimization of peptide API manufacturing processes.

Basic Information

Product Name	2-Fmoc-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	171859-74-8
Molecular Formula	C26H23NO4
Molecular Weight	413.46 g/mol
Synonyms	Fmoc-Tic-OH; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; (3S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; 2-Fmoc-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; N-α-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid; Fmoc-Tic; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Fmoc-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.