Description

3-(9-Fluorenylmethyloxycarbonyl)Amino-3-(2-Nitrophenyl)Propionic Acid is a specialized Fmoc-protected amino acid derivative. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids, particularly for incorporating the unique 3-(2-nitrophenyl)alanine derivative.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including those targeting specific receptors or enzyme inhibitors.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescently labeled or otherwise tagged peptides for imaging and diagnostic applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and protein folding.
• Synthesis of Modified Peptides: Essential for producing peptides containing non-natural or specifically functionalized amino acid residues to enhance stability or biological activity.

Basic Information

Product Name	3-(9-Fluorenylmethyloxycarbonyl)Amino-3-(2-Nitrophenyl)Propionic Acid
CAS No.	171778-06-6
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	Fmoc-3-(2-NO2-Phe)-OH; Fmoc-3-(2-nitrophenyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-nitrophenyl)-L-alanine; 3-(2-Nitrophenyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]alanine; Fmoc-2-Nitrophenylalanine; (2S)-3-(2-Nitrophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
EINECS	Contact for details

Quality Control

Our 3-(9-Fluorenylmethyloxycarbonyl)Amino-3-(2-Nitrophenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.