Description

Proline, 1-Hydroxy-5-Oxo-, Ethyl Ester (9Ci) is a specialized proline derivative, an ethyl ester of a hydroxylated oxoproline, with the CAS registry number 171737-07-8. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, particularly for constructing complex molecules with defined stereochemistry. It is essential for research and development in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular architecture is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially peptidomimetics and protease inhibitors.
• Agrochemical Research: Used in developing novel, biologically active compounds for crop protection and pest management.
• Fine Chemical Synthesis: Employed as a building block for creating complex natural product analogs, flavors, and fragrances.
• Biochemical Research: Acts as a precursor or inhibitor in studies of proline metabolism and related enzymatic pathways.
• Material Science: Potential monomer or modifier for specialty polymers requiring specific functional groups.
• Academic & Contract Research: A critical reagent for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	Proline, 1-Hydroxy-5-Oxo-, Ethyl Ester (9Ci)
CAS No.	171737-07-8
Molecular Formula	C8H11NO5
Molecular Weight	201.18 g/mol
Synonyms	Ethyl 1-Hydroxy-5-oxoproline; Ethyl 1-Hydroxy-5-oxo-L-prolinate; 1-Hydroxy-5-oxoproline Ethyl Ester; 5-Oxo-1-hydroxyproline Ethyl Ester; 1-Hydroxypyroglutamic Acid Ethyl Ester; Ethyl 1-Hydroxypyroglutamate; (S)-1-Hydroxy-5-oxopyrrolidine-2-carboxylic Acid Ethyl Ester; L-1-Hydroxy-5-oxoproline Ethyl Ester
EINECS	Contact for details

Quality Control

Our Proline, 1-Hydroxy-5-Oxo-, Ethyl Ester (9Ci) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.