Description

L-Lysine, N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, Methyl Ester is a protected amino acid derivative, specifically an Fmoc-L-lysine methyl ester, widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is a fundamental raw material for the pharmaceutical, biotechnology, and life science research industries, enabling the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected lysine residue for the controlled elongation of peptide chains, particularly in Fmoc-based methodologies.
• Pharmaceutical Intermediate: Used in the research and GMP-scale production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and infectious diseases.
• Bioconjugation & Labeling: The reactive side-chain amino group, after deprotection, is utilized for site-specific conjugation with fluorescent dyes, polymers, or other bioactive molecules.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery and lead optimization.
• Biochemical Research: Acts as a standard and reagent for studying enzyme kinetics, protein-protein interactions, and post-translational modifications.
• Antibody-Drug Conjugate (ADC) Development: Provides a chemical handle for the precise attachment of cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	L-Lysine, N2-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, Methyl Ester
CAS No.	170943-16-5
Molecular Formula	C22H26N2O5
Molecular Weight	398.46 g/mol
Synonyms	Fmoc-L-Lys-OMe; Fmoc-L-Lysine methyl ester; Nα-Fmoc-L-lysine methyl ester; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid methyl ester; Fmoc-Lys-OMe; Fmoc-Lysine-OMe; N-Fmoc-L-lysine methyl ester; Fmoc-Lys(Alloc)-OH (Note: This is a different, side-chain protected variant)
EINECS	Contact for details

Quality Control

Our Fmoc-L-lysine methyl ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.