Description

4-(Difluoromethoxy)Benzyl Alcohol is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethoxy group can enhance metabolic stability and bioavailability. Pharmaceutical, agrochemical, and specialty chemical R&D departments are the primary industrial sectors that need this high-purity intermediate for their discovery and process development pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy moiety contributes to improved efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and stability.
• Organic Synthesis Reagent: Functions as a protected benzyl alcohol derivative in multi-step synthetic routes for complex molecules.
• Material Science Research: Investigated for creating novel fluorinated organic materials with specific electronic or optical properties.

Basic Information

Product Name	4-(Difluoromethoxy)Benzyl Alcohol
CAS No.	170924-50-2
Molecular Formula	C8H8F2O2
Molecular Weight	174.15 g/mol
Synonyms	α-(Difluoromethoxy)-p-tolyl Alcohol; (4-(Difluoromethoxy)phenyl)methanol; 4-(Difluoromethoxymethyl)phenol (tautomer); p-(Difluoromethoxy)benzyl alcohol; Benzenemethanol, 4-(difluoromethoxy)-; DFMBA; 170924-50-2
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.