Description

Astressin is a potent and selective synthetic peptide antagonist of the corticotropin-releasing factor receptor 1 (CRF1). This compound is a critical research tool for investigating the role of the CRF system in stress-related physiological and behavioral responses. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, endocrinology, and the development of novel therapeutics for anxiety, depression, and related disorders.

Application

• Neuroscience Research: A key pharmacological tool for studying the central and peripheral mechanisms of the stress response via CRF1 receptor blockade.
• Drug Discovery & Development: Used in preclinical studies to validate CRF1 as a therapeutic target and to screen potential novel anxiolytic or antidepressant compounds.
• Endocrinology Studies: Employed to investigate the hypothalamic-pituitary-adrenal (HPA) axis regulation and its dysregulation in stress-related disorders.
• Behavioral Pharmacology: Applied in animal models to assess the effects of CRF antagonism on anxiety-like and depression-like behaviors.
• Biochemical Assays: Serves as a reference standard in receptor binding assays and functional cellular assays to determine agonist/antagonist activity.

Basic Information

Product Name	Astressin
CAS No.	170809-51-5
Molecular Formula	C95H147N31O26S
Molecular Weight	2155.4 g/mol
Synonyms	Astressin; Cyclo(30-33)[D-Phe12,Nle21,38,Glu30,Lys33]Ac-hCRF-(12-41); hCRF-(12-41), Cyclo(30-33)[D-Phe12,Nle21,38,Glu30,Lys33]Ac-; Astressin (cyclic 30-33) peptide; CRF receptor antagonist Astressin; Ac-[D-Phe12,Nle21,38,Glu30,Lys33]hCRF-(12-41) cyclic (30-33) lactam
EINECS	Contact for details

Quality Control

Our Astressin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to ensure compliance with research-grade standards and support your experimental reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Solubility	Soluble in water, DMSO
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.