Description

α-Conotoxin El CAS NO 170663-33-9 is a selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a valuable research tool for studying and characterizing nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems. It is primarily used by researchers in neuroscience, pharmacology, and toxicology for receptor subtype identification, neurological pathway mapping, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Selective blockade of specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes to study their function and distribution.
• Pharmacological Studies: Used as a molecular probe to investigate receptor-ligand interactions, signal transduction, and the mechanisms of cholinergic neurotransmission.
• Drug Discovery & Development: Serves as a lead compound or template for designing novel analgesics, neuroprotective agents, or treatments for neurological disorders.
• Toxicology & Venom Research: Analysis of conotoxin structure-activity relationships (SAR) and the mechanisms of action of marine snail venoms.
• Biochemical Assay Development: Utilized in the creation of high-throughput screening assays for identifying new nAChR modulators.
• Academic & Institutional Research: Fundamental research in universities and institutes exploring synaptic transmission, pain pathways, and neurobiology.

Basic Information

Product Name	α-Conotoxin El
CAS No.	170663-33-9
Molecular Formula	C71H111N23O21S5
Molecular Weight	1682.1 g/mol
Synonyms	α-Conotoxin El; α-Conotoxin EI; Conotoxin EI; α-CTx El; EI Conotoxin; Alpha Conotoxin from Conus ermineus; Nicotinic Acetylcholine Receptor Antagonist, α-CTx; [Arg14]-α-Conotoxin EI
EINECS	Contact for details

Quality Control

Our α-Conotoxin El is produced and tested to meet the stringent requirements of research and pre-clinical applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, including data from HPLC, MS, and amino acid analysis, confirming compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere or under vacuum.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Sequence	GCCSHPACSVNNPDIC-NH2 (Disulfide bridges: Cys2-Cys8, Cys3-Cys16)
Molecular Weight	1682.1 ± 1.0 Da
Solubility	Soluble in water or aqueous buffers
Biological Activity	Verified by functional assay (e.g., nAChR inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.